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Researchers are currently investigating the role of cytokine expression levels in diseases such as cancer, AIDS, and autoimmune diseases. Cytokines are crucial in cellular communication and are key elements in controlling the immune response. Research suggests that polymorphic variants of cytokine genes may be associated with acute and chronic transplant rejection. These variants express the corresponding cytokine gene at either elevated or reduced levels. Expression levels of TGF-beta, TNF-alpha, IL-10, and IL-6 appear to affect the likelihood of organ rejection.1 Genotyping of these polymorphic variants might be used to further investigate the role of cytokines in organ transplants.
The Cytokine Genotyping tray provides an accurate, simple, and economical means of detecting polymorphisms of the following cytokine genes: