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LABScreen Multi is a screening tool for antibodies against both the HLA and Human Neutrophil Antigens (HNA). Antibodies against HNA are implicated in a variety of clinical conditions, including Transfusion Related Acute Lung Injury (TRALI). This mulitplex assay qualitatively measures the presence of specific HLA/HNA antibodies in a human serum or plasma sample.Contact Us About This Product
LABScreen reagents are powered by Luminex® xMAP® technology, a microbead platform used to deliver multiplex antibody assays in high-PRA patients. This single antigen-bead based assay allows for a precise determination of antibody profiles against HLA and HNA.
Current research reports that both anti-HLA and anti-HNA antibodies have been implicated in clinical cases of transfusion related acute lung injury (TRALI*).
Fromont P, Prié N, Simon P, et al. Granulocyte antibody screening: evaluation of a bead-based assay in comparison with classical methods. Transfusion. 2010;50(12):2643-8.
AABB's TRALI mitigation strategies...