Featured Scientific Research

Estimating Alloantibody Levels in Highly-Sensitized Renal Allograft Candidates: Using Serial Dilutions to Demonstrate a Treatment Effect in Clinical Trials

This study used serial dilution analysis to determine the point at which cPRA could be reduced below 98%, a value previously shown to significantly increase probability of transplant.

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Discovering novel injury features in kidney transplant biopsies associated with TCMR and donor aging

We conclude that genome-wide measurements in the MMDx system can be used not only to assess rejection but can also offer clinically useful insights into parenchymal injury at no extra cost by developing software tools.

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HLA Antibody Detection with Solid Phase Assays: Great Expectations or Expectations Too Great?

Alloantibodies directed against HLA antigens, are a barrier to long-term solid organ allograft survival... HLA antibodies are key factors that limit patient access to donor organs...

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Development and Validation of a Multiplex, Bead-Based Assay to Detect Antibodies Directed Against SARS-CoV-2 Proteins

The SARS-CoV-2 genome encodes four major structural proteins; spike, envelope, membrane, and nucleocapsid. Most commercially available tests target either the spike subunits or nucleocapsid.

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Antibodies against AT1-receptor in transplantation (diagnostics, treatment, clinical relevance).

The use of eluates for antibody detection was more sensitive and more reliable than patient serum. Yet, the test results are only meaningful when AB titres are measured, as this allows for a quick statement about the actual antibody elimination. The removal of pathogenic aAB via IA is better than medication-based treatment.

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