Featured Scientific Research

Intensity of de novo DSA detected by Immucor Lifecodes assay and C3d fixing antibodies are not predictive of subclinical ABMR after kidney transplantation

Summary Series (2021/08)
Bertrand et al. demonstrate that there are significant differenc-es between HLA antibody test vendors in ability to detect dnDSA in cases of biopsy proven sABMR..

Research suggests HLA & HNA may play a critical role in COVID-19 Susceptibility, Immune Protection and Success of Novel Treatments during a Global Pandemic Crisis

White Paper (2021/06)
As the current COVID-19 pandemic evolves, research is indicating that HLA type may play an integral role in population level immune monitoring and vaccine development.

Incidence and impact of allele-specific anti-HLA antibodies and high-resolution HLA genotyping on assessing immunologic compatibility

Summary Series (2021/04)
Here the authors have demonstrated that HLA allele-specific antibodies with reactivity outside of the standard SAB panels are not uncommon and that screening with reagents beyond the standard SAB may be necessary for sensitized patients.

Discrepancy analysis comparing molecular and histology diagnoses in kidney transplant biopsies

Summary Series (2021/03)
This study demonstrates the reproducibility of MMDx and the lack of significant disagreement between MMDx sign outs.

Analysis of RNA Transcripts by the Molecular Microscope® Diagnostic System (MMDx®) Can Direct Management after Indication Kidney Transplant Biopsy

Summary Series (2021/03)
These two cases describe how MMDx was used to aid the management of two patients with Banff diagnoses of “borderline” and “Banff 1a TCMR.”

COVID Plus: A New Diagnostic Tool to Protect Transplant Patients in the Fight Against COVID-19

White Paper (2021/02)
We must consider, therefore, that a COVID-19 infection, as well as any future COVID-19 vaccine, may trigger changes in HLA antibody profiles. This, in turn, may have a profound effect on patients’ eligibility for transplant and risk of rejection after transplant.

Revisiting the changes in the Banff Classification for antibody‐mediated rejection after kidney transplantation

Summary Series (2021/02)
This study highlights the over simplification of the diagnosis of ABMR leading to a group of patients with less good outcomes being reclassified as ‘no ABMR’. The Molecular Microscope® Diagnostic System (MMDx) may resolve these issues by providing a clear molecular interpretation of the phenotype of rejection and extent of injury.

Gene Expression Profiling for the Identification and Classification of Antibody-Mediated Heart Rejection

Summary Series (2021/02)
Tissue-level molecular analysis of heart transplant biopsies with MMDx correlates with ISHLT grade of AMR but identifies important discrepancies. MMDx is a tool for personalized, precision diagnostics and is useful for designing and testing novel therapeutic interventions.

Amplifying the Patient Voice: Key Priorities and Opportunities for Improved Transplant and Living Donor Advocacy and Outcomes During COVID-19 and Beyond

Summary Series (2021/01)
Defining patient advocacy and engagement for modern transplant and living donation care, particularly in light of the COVID-19 pandemic.

Estimating Alloantibody Levels in Highly-Sensitized Renal Allograft Candidates: Using Serial Dilutions to Demonstrate a Treatment Effect in Clinical Trials

Summary Series (2021/01)
This study used serial dilution analysis to determine the point at which cPRA could be reduced below 98%, a value previously shown to significantly increase probability of transplant.

 


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